Adams-Oliver syndrome was first described by Dr. Forrest H. Adams and Dr. C. P. Oliver in 1945. They reported a family with various limb and scalp defects over four generations (
Adams and Oliver, 1945). Between 1945 when Adams-Oliver syndrome was first documented and 2000, there have been only 125 cases of Adams-Oliver syndrome reported in literature.
Because the gene(s) affected by Adams-Oliver syndrome has not yet been identified and there are so few reported cases, there are still a lot of unknown facts surrounding complications, causes, and effects of Adams-Oliver syndrome. It is believed that the complications found in individuals with Adams-Oliver syndrome are a result of vascular abnormalities during embryonic development (
Swartz et al., 1999, and Toriello et al., 1988). These vascular abnormalities result in a various anomalies.
